MULTIPLATE PUBLICATIONS
Full papers, short communications
Studies in 2011
Studies in 2010
Studies in 2009
Studies in 2008
Studies in 2007
Studies in 2006
2011-09 Chen F, Maridakis V, O'neill EA, Beals C, Radziszewski W, de Lepeleire I, Van Dyck K, Depré M, Bolognese JA, de Hoon J, Jacquemin M. A randomized clinical trial comparing point-of-care platelet function assays and bleeding time in healthy subjects treated with aspirin or clopidogrel. Platelets. 2011 Sep 15.[Epub ahead of print]
2011-09 Park Y, Jeong YH, Kim IS, Yun SE, Jung Kwon T, Hwang SJ, Hwan Kwak C, Hwang JY. The concordance and correlation of measurements by multiple electrode and light transmittance aggregometries based on the pre-defined cutoffs of high and low on-treatment platelet reactivity. Platelets. 2011 Sep 26. [Epub ahead of print]
2011-09 Würtz M, Hvas AM, Kristensen SD, Grove EL. Platelet aggregation is dependent on platelet count in patients with coronary artery disease. Thromb Res. 2011 Sep 12. [Epub ahead of print]
2011-08 Edwards A, Jakubowski JA, Rechner AR, Sugidachi A, Harrison P. Evaluation of the INNOVANCE PFA P2Y test cartridge: Sensitivity to P2Y(12) blockade and influence of anticoagulant. Platelets. 2011 Aug 17. [Epub ahead of print]
2011-08 Kafian S, Mobarrez F, Kalani M, Wallén H, Samad BA. Comparison of venous and arterial blood sampling for the assessment of platelet aggregation with whole blood impedance aggregometry. Scand J Clin Lab Invest. 2011 Aug 28. [Epub ahead of print]
2011-08 Djukanovic N, Todorovic Z, Obradovic S, Zamaklar-Trifunovic D, Njegomirovic S, Milic NM, Prostran M, Ostojic M. Abrupt Cessation of One-Year Clopidogrel Treatment Is Not Associated With Thrombotic Events. J Pharmacol Sci. 2011 Aug 6.[Epub ahead of print]
2011-08 Bernlochner I, Byrne RA, Kastrati A, Sibbing D. The future of platelet function testing to guide therapy in clopidogrel low and enhanced responders.Expert Rev Cardiovasc Ther. 2011 Aug;9(8):999-1014.
2011-08 Jilma-Stohlawetz P, Gilbert JC, Gorczyca ME, Knöbl P, Jilma B. A dose ranging phase I/II trial of the von Willebrand factor inhibiting aptamer ARC1779 in patients with congenital thrombotic thrombocytopenic purpura. Throm Haemost.2011 Aug 11;106(3).
2011-08 Gasparovic H, Petricevic M, Biocina B. Reduction of thienopyridine-associated bleeding using multiple electrode whole-blood aggregometry. Ann Thorac Surg. 2011 Aug;92(2):778-9.
2011-08 Schober LJ, Khandoga AL, Dwivedi S, Penz SM, Maruyama T, Brandl R, Siess W. The role of PGE(2) in human atherosclerotic plaque on platelet EP(3) and EP (4)receptor activation and platelet function in whole blood. J Thromb Thrombolysis. 2011 Aug;32(2):158-66.
2011-08 Würtz M, Wulff LN, Grove EL, Kristensen SD, Hvas AM. Influence of renal function and platelet turnover on the antiplatelet effect of aspirin. Thromb Res.2011 Aug 10.
2011-08 Ueno M, Ferreiro JL, Tomasello SD, Tello-Montoliu A, Capodanno D, Seecheran N, Kodali M, Dharmashankar K, Desai B, Charlton RK, Bass TA, Angiolillo DJ. Impact of pentoxifylline on platelet function profiles in patients with type 2 diabetes mellitus and coronary artery disease on dual antiplatelet therapy with aspirin and clopidogrel. JACC Cardiovasc Interv. 2011 Aug;4(8):905-12.
2011-08 Gremmel T, Panzer S. Clinical, genetic and confounding factors determine the dynamics of the in vitro response/non response to clopidogrel. Thromb Haemost. 2011 Aug 1;106(2):211-8.
2011-07 Mäntysaari M, Joutsi-Korhonen L, Siimes MA, Siitonen S, Parkkola K, Lemponen M, Lassila R. Unaltered blood coagulation and platelet function in healthy subjects exposed to acute hypoxia. Aviat Space Environ Med. 2011 Jul;82(7):699-703.
2011-07 Lukasik M, Dworacki G, Michalak S, Kufel-Grabowska J, Golanski J, Watala C, Kozubski W. Aspirin treatment influences platelet-related inflammatory biomarkers in healthy individuals but not in acute stroke patients. Thromb Res. 2011 Jul 23.
2011-07 Orban M, Byrne RA, Hausleiter J, Laugwitz KL, Sibbing D. Massive thrombus burden with recurrence of intracoronary thrombosis early after stenting and delayed onset of prasugrel action in a patient with ST-elevation myocardial infarction and cardiac shock. Thromb Haemost. 2011 Jul 4;106(3).
2011-07 Correia-da-Silva M, Sousa E, Duarte B, Marques F, Carvalho F, Cunha-Ribeiro LM, Pinto MM. Polysulfated Xanthones: Multipathway Development of a New Generation of Dual Anticoagulant/Antiplatelet Agents J Med Chem. 2011 Aug 11;54(15):5373-5384.
2011-06 Sibbing D, Byrne RA, Kastrati A. Role of Platelet Function Testing in Clinical Practice: CurrentConcepts and Future Perspectives. Curr Drug Targets. 2011 Jun 30. [Epub ahead of print]
2011-06 Gurbel PA, Tantry US. Clopidogrel response variability and the advent of personalised antiplatelet therapy. A bench to bedside journey. Thromb Haemost. 2011 Jun 28;106(2).
2011-06 Hofer A, Kozek-Langenecker S, Schaden E, Panholzer M, Gombotz H. Point-of-care assessment of platelet aggregation in paediatric open heart surgery. Br J Anaesth. 2011 Jun 22. [Epub ahead of print]
2011-06 Kim JE, Han M, Hanl KS, Kim HK. Vitamin E inhibition on platelet procoagulant activity: involvement of aminophospholipid translocase activity. Thromb Res. 2011 May;127(5):435-42.
2011-06 Robier C, Strohmeier L, Quehenberger F, Neubauer M, Stettin M, Rainer F. The effect of intravenous high-dose methylprednisolone on platelet reactivity assessed with multiple electrode aggregometry. Thromb Haemost. 2011 Jun 6;105(6):1110-1.
2011-06 Valarche V, Desconclois C, Boutekedjiret T, Dreyfus M, Proulle V. Multiplate(®) whole blood impedance aggregometry: a new tool for von Willebrand disease. J Thromb Haemost. 2011 Aug;9(8):1645-7.
2011-06 Kuliczkowski W, Greif M, Gąsior M, Kaczmarski J, Pres D, Poloński L. Effects of platelet and inflammatory system activation on outcomes in diabetic patients with ST segment elevation myocardial infarction treated with primary percutaneous coronary intervention. Kardiol Pol. 2011;69(6):531-7.
2011-06 Solomon C, Traintinger S, Ziegler B, Hanke A, Rahe-Meyer N, Voelckel W, Schöchl H. Platelet function following trauma. A Multiple Electrode Aggregometry study. Thromb Haemost. 2011 Jun 9;106(2).
2011-06 Kim CW, Yun JW, Bae IH, Park YH, Jeong YS, Park JW, Chung JH, Park YH, Lim KM. Evaluation of anti-platelet and anti-thrombotic effects of cilostazol with PFA-100® and Multiplate® whole blood aggregometer in vitro, ex vivo and FeCl3-induced thrombosis models in vivo. Thromb Res. 2011 Jun;127(6):565-70.
2011-05 Freynhofer MK, Brozovic I, Bruno V, Farhan S, Vogel B, Jakl G, Willheim M, Hübl W, Wojta J, Huber K. Multiple electrode aggregometry and vasodilator stimulated phosphoprotein-phosphorylation assay in clinical routine for prediction of postprocedural major adverse cardiovascular events. Thromb Haemost. 2011 May 26;106(2).
2011-05 Oscarsson A, Oster S, Fredrikson M, Lindahl TL, Eintrei C. Platelet function assessed by whole-blood aggregometry in patients undergoing non-cardiac surgery. Eur J Anaesthesiol 2011 May; 28(5),363-9.
2011-05 Luzak B, Boncler M, Rywaniak J, Wilk R, Stanczyk L, Czyz M, Rysz J, Watala C. The effect of a platelet cholesterol modulation on the acetylsalicylic acid-mediated blood platelet inhibition in hypercholesterolemic patients. Eur J Pharmacol. 2011 May 11;658(2-3):91-7.
2011-05 Kilickesmez KO, Kocas C, Okcun B, Abaci O, Kaya A, Arat A, Gorcin B, Gurmen T. Laboratory signs of aspirin response in haemodialysis patients. Scand J Clin Lab Invest.2011 Sep;71(5):426-31.
2011-04 Gurbel PA, Mahla E, Tantry US. Peri-operative platelet function testing: The potential for reducing ischaemic and bleeding risks. Thromb Haemost. 2011 Apr 20;106(1).
2011-04 Haselboeck J, Pabinger I, Ay C, Koder S, Panzer S. Platelet activation and function during eltrombopag treatment in immune thrombocytopenia. Ann Hematol. 2011 May 7. [Epub ahead of print]
2011-04 Behr T, Kuch B, Behr W, von Scheidt W. Optimizing of thienopyridine therapy by multiple electrode platelet aggregometry in clopidogrel low responders undergoing PCI. Clin Res Cardiol 2011 Apr 30. [Epub ahead of print]
2011-04 Sibbing D, Koch W, Massberg S, Byrne RA, Mehilli J, Schulz S, Mayer K, Bernlochner I, Schömig A, Kastrati A. No association of paraoxonase-1 Q192R genotypes with platelet response to clopidogrel and risk of stent thrombosis after coronary stenting. Eur Heart J. 2011 Jul;32(13):1605-13.
2011-04 Jámbor C, von Pape KW, Spannagl M, Dietrich W, Giebl A, Weisser H. Multiple Electrode Whole Blood Aggregometry, PFA-100, and In Vivo Bleeding Time for the Point-of-Care Assessment of Aspirin-Induced Platelet Dysfunction in the Preoperative Setting. Anesth Analg. 2011 Jul;113(1):31-9.
2011-04 Sibbing D, Byrne RA, Bernlochner I, Kastrati A. High platelet reactivity and clinical outcome - Fact and fiction. Thromb Haemost. 2011 Apr 20;106(1).
2011-04 Ayik F, Oguz E, Engin C, Yagdi T, Ulger Z, Atay Y, Ozbaran M. Surgical therapy of end-stage heart failure in pediatric patients. Transplant Proc 2011 Apr;43(3):935-7.
2011-04 Diehl P, Halscheid C, Olivier C, Helbing T, Bode C, Moser M. Discontinuation of long term clopidogrel therapy induces platelet rebound hyperaggregability between 2 and 6 weeks post cessation. Clin Res Cardiol 2011 Apr 9. [Epub ahead of print]
2011-04 Bochsen L, Johansson PI, Kristensen AT, Daugaard G, Ostrowski SR. The influence of platelets, plasma and red blood cells on functional haemostatic assays. Blood Coagul Fibrinolysis 2011 Apr;22(3):167-75.
2011-04 Schedel A, Thornton S, Schloss P, Klüter H, Bugert P. Human platelets express functional alpha7-nicotinic acetylcholine receptors. Arterioscler Thromb Vasc Biol. 2011 Apr;31(4):928-34.
2011-04 Lison S, Weiss G, Spannagl M, Heindl B. Postoperative changes in procoagulant factors after major surgery. Blood Coagul Fibrinolysis 2011 Apr;22(3):190-6.
2011-04 Tselepis AD, Gerotziafas G, Andrikopoulos G, Anninos H, Vardas P. Mechanisms of platelet activation and modification of response to antiplatelet agents. Hellenic J Cardiol. 2011 Mar-Apr;52(2):128-40.
2011-03 Sarafoff N, Neumann L, Morath T, Bernlochner I, Mehilli J, Schömig A, Kastrati A, Sibbing D. Lack of impact of calcium-channel blockers on the pharmacodynamic effect and the clinical efficacy of clopidogrel after drug-eluting stenting. Am Heart J 2011 Mar;161(3):605-10.
2011-03 Correia-da-Silva M, Sousa E, Duarte B, Marques F, Cunha-Ribeiro LM, Pinto MM. Dual anticoagulant/antiplatelet persulfated small molecules. Eur J Med Chem. 2011 Jun;46(6):2347-58.
2011-03 Stissing T, Dridi NP, Ostrowski SR, Bochsen L, Johansson PI. The Influence of Low Platelet Count on Whole Blood Aggregometry Assessed by Multiplate. Clin Appl Thromb Hemost 2011 Mar 14. [Epub ahead of print].
2011-03 Boncler M, Rywaniak J, Sicinska P, Watala C. Effectiveness of modified C-reactive protein in the modulation of platelet function under different experimental conditions. Blood Coagul Fibrinolysis 2011 Mar 2. [Epub ahead of print].
2011-02 Ferrer-Marin F, Chavda C, Lampa M, Michelson AD, Frelinger Iii AL, Sola-Visner M. Effects of in-vitro adult platelet transfusions on neonatal hemostasis. J Thromb Haemost 2011 May;9(5):1020-8.
2011-02 Hanke AA, Maschler S, Schöchl H, Flöricke F, Görlinger K, Zanger K, Kienbaum P. In Vitro impairment of whole blood coagulation and platelet function by hypertonic saline hydroxyethyl starch. Scand J Trauma Resusc Emerg Med 2011 Feb 10;19:12.
2011-02 Kuiper GJ, Lancé MD, Smit-Fun VM, Peeters LL, Marcus MA. Platelet monitoring follow-up in a pregnant patient with HELLP syndrome. Platelets 22(2), 160-3.
2011-02 Ko YG, Suh JW, Kim BH, Lee CJ, Kim JS, Choi D, Hong MK, Seo MK, Youn TJ, Chae IH, Choi DJ, Jang Y. Comparison of 2 point-of-care platelet function tests, VerifyNow Assay and Multiple Electrode Platelet Aggregometry, for predicting early clinical outcomes in patients undergoing percutaneous coronary intervention. Am Heart J 2011 Feb;161(2):383-90.
2011-02 Gertler R, Wiesner G, Tassani-Prell P, Braun SL, Martin K. Are the Point-of-Care Diagnostics MULTIPLATE and ROTEM Valid in the Setting of High Concentrations of Heparin and Its Reversal With Protamine? J Cardiothorac Vasc Anesth 2011 Feb 9. [Epub ahead of print].
2011-02 Mengistu AM, Mayer J, Boldt J, Röhm KD, Suttner SW. Usefulness of monitoring platelet function by multiple electrode aggregometry in primary coronary artery bypass surgery. J Cardiothorac Vasc Anesth 2011 Feb;25(1):42-7.
2011-02 Spiel Spiel AO, Bartko J, Schwameis M, Firbas C, Siller-Matula J, Schuetz M, Weigl M, Jilma B. Increased platelet aggregation and in vivo platelet activation after granulocyte colony-stimulating factor administration. A randomised controlled trial. Thromb Haemost 2011 Apr 4;105(4):655-62. Epub 2011 Feb 8.
2011-02 Reece MJ, Klein AA, Salviz EA, Hastings A, Ashworth A, Freeman C, Luddington RJ, Nair S, Besser MW. Near-patient platelet function testing in patients undergoing coronary artery surgery: a pilot study. Anaesthesia 2011 Feb;66(2):97-103.
2011-01 Gremmel T, Steiner S, Seidinger D, Koppensteiner R, Panzer S, Kopp CW. Comparison of methods to evaluate aspirin-mediated platelet inhibition after percutaneous intervention with stent implantation. Platelets 2011;22(3):188-95.
2011-01 Ranucci M, Baryshnikova E, Soro G, Ballotta A, De Benedetti D, Conti D; Surgical and Clinical Outcome Research (SCORE) Group. Multiple electrode whole-blood aggregometry and bleeding in cardiac surgery patients receiving thienopyridines. Ann Thorac Surg 91(1), 123-9.
2011-01 Bauer NB, Er E, Moritz A. Influence of blood collection technique on platelet function and coagulation variables in dogs. Am J Vet Res 2011 Jan;72(1):64-72.
2011-01 Ulehlova J, Slavik L, Krcova V, Hutyra M, Galuszka J, Indrak K. The assessment of aspirin resistance by using light transmission and multiple electrode aggregometry. Int J Lab Hematol 2011 Jun;33(3):305-9. Epub 2011 Jan 11.
2011-01 Grove EL, Hvas AM, Mortensen SB, Larsen SB, Kristensen SD. Effect of platelet turnover on whole blood platelet aggregation in patients with coronary artery disease. J Thromb Haemost 2011 Jan;9(1):185-91.
2011-01 Weber CF, Görlinger K, Byhahn C, Moritz A, Hanke AA, Zacharowski K, Meininger D. Tranexamic acid partially improves platelet function in patients treated with dual antiplatelet therapy. Eur J Anaesthesiol 2011 Jan;28(1):57-62.
2010-12 Bampalis VG, Khandoga AL, Siess W. Fluoxetine inhibition of 5-HT-potentiated platelet aggregation in whole blood. Thromb Haemost 2010 Dec;104(6):1272-4.
2010-12 Awidi Awidi A, Saleh A, Dweik M, Kailani B, Abu-Fara M, Nabulsi R, Bener A. Measurement of platelet reactivity of patients with cardiovascular disease on-treatment with acetyl salicylic acid: a prospective study. Heart Vessels 2010 Dec 23. [Epub ahead of print]
2010-12 Dwivedi S, Pandey D, Khandoga AL, Brandl R, Siess W. Rac1-mediated signaling plays a central role in secretion-dependent platelet aggregation in human blood stimulated by atherosclerotic plaque. J Transl Med 2010 Dec 6;8:128.
2010-12 De Luca G, Secco GG, Santagostino M, Venegoni L, Iorio S, Cassetti E, Verdoia M, Coppo L, Di Mario C, Bellomo G, Marino P; on behalf of the Novara Atherosclerosis Study Group (NAS). Uric acid does not affect the prevalence and extent of coronary artery disease. Results from a prospective study. Nutr Metab Cardiovasc Dis 2010 Dec 24. [Epub ahead of print]
2010-12 Weber CF, Jámbor C, Strasser C, Moritz A, Papadopoulos N, Zacharowski K, Meininger D. Normovolemic modified ultrafiltration is associated with better preserved platelet function and less postoperative blood loss in patients undergoing complex cardiac surgery: A randomized and controlled study. J Thorac Cardiovasc Surg 2011 May;141(5):1298-304. Epub 2010 Dec 3.
2010-12 Ignjatovic VS, Petrovic N, Miloradovic V, Ignjatovic S, Cokanovic V, Grdinic A, Simic I, Petrovic I, Nikolic S, Andjelkovic A, Paramentic D, Ignjatovic S. The influence of bisoprolol dose on ADP-induced platelet aggregability in patients on dual antiplatelet therapy. Coron Artery Dis 2010 Dec;21(8):472-6.
2010-12 Bernlochner I, Steinhubl S, Braun S, Morath T, Jaitner J, Stegherr J, Mehilli J, von Beckerath N, Schömig A, Kastrati A, Sibbing D. Association between inflammatory biomarkers and platelet aggregation in patients under chronic clopidogrel treatment. Thromb Haemost 2010 Dec;104(6):1193-200.
2010-12 Weber CF, Hampp K, Zacharowski K, Pape A, lindhoff-Last E, Moritz A, _Hanke AA, Hofstetter C. Evaluation of multiple electrode aggregometry for the perioperative assessment of aspirin therapy in cardiac surgery. Applied Cardiopulmonary Pathophysiology 14: 163-173, 2010.
2010-11 Keyl C, Kmitta E, Kueri S, Zietak T, Trenk D. Effects of aspirin and desmopressin on platelet reactivity in patients undergoing cardiac surgery with extracorporeal circulation. Thromb Haemost 2011 Jan 3;105(1):113-21. Epub 2010 Nov 5.
2010-11 De Luca G, Santagostino M, Secco GG, Cassetti E, Giuliani L, Coppo L, Schaffer A, Fundaliotis A, Iorio S, Venegoni L, Bellomo G, Marino P. Platelet-Large Cell Ratio and the extent of coronary artery disease: results from a large prospective study. J Thromb Thrombolysis 2010 Nov;30(4):426-33.
2010-11 Gremmel T, Steiner S, Seidinger D, Koppensteiner R, Panzer S, Kopp CW. The Influence of Proton Pump Inhibitors on the Antiplatelet Potency of Clopidogrel Evaluated by Five Different Platelet Function Tests. J Cardiovasc Pharmacol 2010 Nov;56(5):532-9.
2010-11 Cañigral A, Silvestre FJ, Cañigral G, Alós M, Garcia-Herraiz A, Plaza A. Evaluation of bleeding risk and measurement methods in dental patients. Med Oral Patol Oral Cir Bucal 2010 Nov 1;15(6):e863-8.
2010-10 Jaitner J, Stegherr J, Morath T, Braun S, Bernlochner I, Schömig A, Kastrati A, Sibbing D. Stability of the high on-treatment platelet reactivity phenotype over time in clopidogrel-treated patients. Thromb Haemost 2011 Jan 3;105(1):107-12. Epub 2010 Oct 26.
2010-10 Schöchl H, Posch A, Hanke A, Voelckel W, Solomon C. High-dose fibrinogen concentrate for haemostatic therapy of a major trauma patient with recent clopidogrel and aspirin intake. Scand J Clin Lab Invest 2010 Oct;70(6):453-7.
2010-09 Aradi D, Komócsi A, Vorobcsuk A, Rideg O, Tokés-Füzesi M, Magyarlaki T, Horváth IG, Serebruany VL. Prognostic significance of high on-clopidogrel platelet reactivity after percutaneous coronary intervention: systematic review and meta-analysis. Am Heart J. 2010 Sep;160(3):543-51. Review.
2010-09 Winterhalter M, Malinski P, Danzeisen O, Sixt S, Monaca E, Jüttner T, Peiper M, Kienbaum P, Koester A, Rahe-Meyer N. Prospective Observational Study for Perioperative Volume Replacement with 6% HES 130/0,42, 4% Gelatin and 6% HES 200/0,5 in Cardiac Surgery. Eur J Med Res 2010 Sep 24;15(9):383-9.
2010-09 Bonello L, Tantry US, Marcucci R, Blindt R, Angiolillo DJ, Becker R, Bhatt DL, Cattaneo M, Collet JP, Cuisset T, Gachet C, Montalescot G, Jennings LK, Kereiakes D, Sibbing D, Trenk D, Van Werkum JW, Paganelli F, Price MJ, Waksman R, Gurbel PA; Working Group on High On-Treatment Platelet Reactivity. Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate. J Am Coll Cardiol 2010 Sep 14;56(12):919-33.
2010-09 Schlagenhauf A, Schweintzger S, Birner-Gruenberger R, Leschnik B, Muntean W. Newborn platelets: Lower levels of protease-activated receptors cause hypoaggregability to thrombin. Platelets 2010;21(8):641-7.
2010-09 Hofer CK, Zollinger A, Ganter MT. Perioperative assessment of platelet function in patients under antiplatelet therapy. Expert Rev Med Devices 2010 Sep;7(5):625-37.
2010-08 Schulz S, Sibbing D, Braun S, Morath T, Mehilli J, Massberg S, Byrne RA, Schömig A, Kastrati A. Platelet response to clopidogrel and restenosis in patients treated predominantly with drug-eluting stents. Am Heart J 2010 Aug;160(2):355-61.
2010-08 Loreth RM, Klose G. Comparison of Two Different Blood Sample Tubes for Platelet Function Analysis with the Multiplate® System. Transfus Med Hemother 2010;37(5):289-292.
2010-08 Würtz M, Grove EL, Wulff LN, Kaltoft AK, Tilsted HH, Jensen LO, Hvas AM, Kristensen SD. Patients with previous definite stent thrombosis have a reduced antiplatelet effect of aspirin and a larger fraction of immature platelets. JACC Cardiovasc Interv 2010 Aug;3(8):828-35.
2010-08 Frelinger AL 3rd, Barnard MR, Fox ML, Michelson AD. The Platelet Activity After Clopidogrel Termination (PACT) Study. Circ Cardiovasc Interv 2010 Oct;3(5):442-9. Epub 2010 Aug 24.
2010-08 Ostrowski SR, Bochsen L, Windeløv NA, Salado-Jimena JA, Reynaerts I, Goodrich RP, Johansson PI. Hemostatic function of buffy coat platelets in additive solution treated with pathogen reduction technology. Transfusion 2011 Feb;51(2):344-56. Epub 2010 Aug 16.
2010-07 Müller K, Aichele S, Herkommer M, Bigalke B, Stellos K, Htun P, Fateh-Moghadam S, May AE, Flather M, Gawaz M, Geisler T. Impact of inflammatory markers on platelet inhibition and cardiovascular outcome including stent thrombosis in patients with symptomatic coronary artery disease. Atherosclerosis 2010 Nov;213(1):256-62. Epub 2010 Jul 27.
2010-07 Wenaweser P, Eshtehardi P, Abrecht L, Zwahlen M, Schmidlin K, Windecker S, Meier B, Haeberli A, Hess OM. A randomised determination of the Effect of Fluvastatin and Atorvastatin on top of dual antiplatelet treatment on platelet aggregation after implantation of coronary drug-eluting stents. The EFA-Trial. Thromb Haemost 2010 Sep;104(3):554-62. Epub 2010 Jul 20.
2010-07 Robier C, Neubauer M, Sternad H, Quehenberger F, Rainer F, Neumeister P. Evaluation of platelet function and pharmacological platelet inhibition in patients with myeloproliferative disorders using multiple electrode aggregometry. Thromb Res 2010 Sep;126(3):232-7. Epub 2010 Jul 13.
2010-07 Sibbing D, Steinhubl SR, Schulz S, Schömig A, Kastrati A. Platelet aggregation and its association with stent thrombosis and bleeding in clopidogrel-treated patients initial evidence of a therapeutic window. J Am Coll Cardiol 2010 Jul 20;56(4):317-8.
2010-07 Schedel A, Thornton S, Klüter H, Bugert P. The Effect of Psychoactive Drugs on in vitro Platelet Function. Transfus Med Hemother. 2010;37(5):293-298.
2010-07 Matsota P, Politou M, Kalimeris K, Apostolaki S, Merkouri E, Gialeraki A, Travlou A, Kostopanagiotou G. Do different substitution patterns or plant origin in hydroxyethyl starches affect blood coagulation in vitro? Blood Coagul Fibrinolysis. 2010 Jul;21(5):448-51.
2010-06 Ferreiro JL, Sibbing D, Angiolillo DJ. Platelet function testing and risk of bleeding complications. Thromb Haemost 2010 Jun;103(6):1128-35.
2010-06 Boldt J, Mayer J, Brosch C, Lehmann A, Mengistu A. Volume replacement with a balanced hydroxyethyl starch (HES) preparation in cardiac surgery patients. J Cardiothorac Vasc Anesth 2010 Jun;24(3):399-407.
2010-06 Chung S, Kim JE, Kim JY, Lee DS, Han KS, Kim HK. Circulating hepatocyte growth factor as an independent prognostic factor of disseminated intravascular coagulation. Thromb Res 2010 Jun;125(6):e285-93.
2010-06 Fröbert O, Christensen K, Fahlman A, Brunberg S, Josefsson J, Särndahl E, Swenson JE, Arnemo JM.Platelet function in brown bear (Ursus arctos) compared to man. Thromb J 2010 Jun 2;8:11.
2010-06 Geisler T, Mueller K, Aichele S, Bigalke B, Stellos K, Htun P, Ninci E, Fateh-Moghadam S, May AE, Gawaz M. Impact of inflammatory state and metabolic control on responsiveness to dual antiplatelet therapy in type 2 diabetics after PCI: prognostic relevance of residual platelet aggregability in diabetics undergoing coronary interventions. Clin Res Cardiol. 2010 Nov;99(11):743-52. Epub 2010 Jun 6. Erratum in: Clin Res Cardiol 2010 Nov;99(11):769. Epub 2010 Jun 6.
2010-06 Karlsson M, Ternström L, Hyllner M, Baghaei F, Skrtic S, Jeppsson A. Prophylactic Fibrinogen Infusion in Cardiac Surgery Patients: Effects on Biomarkers of Coagulation, Fibrinolysis, and Platelet Function. Clin Appl Thromb Hemost 2010 Jun 7. [Epub ahead of print]
2010-06 Czura CJ, Schultz A, Kaipel M, Khadem A, Huston JM, Pavlov VA, Redl H, Tracey KJ. Vagus nerve stimulation regulates hemostasis in swine. Shock 2010 Jun;33(6):608-13.
2010-05 Althoff TF, Fischer M, Langer E, Ziemer S, Baumann G. Sustained enhancement of residual platelet reactivity after coronary stenting in patients with myocardial infarction compared to elective patients. Thromb Res 2010 May;125(5):e190-6.
2010-05 Boeer K, Reinhöfer M, Lösche W. Validation of a procedure to assess ASA-response in patients with decreased, initial TRAP induced aggregation. Platelets 2010;21(5):314-9.
2010-05 Diehl P, Olivier C, Halscheid C, Helbing T, Bode C, Moser M. Clopidogrel affects leukocyte dependent platelet aggregation by P2Y12 expressing leukocytes. Basic Res Cardiol 2010 May;105(3):379-87.
2010-05 Eshtehardi P, Windecker S, Cook S, Billinger M, Togni M, Garachemani A, Meier B, Hess OM, Wenaweser P. Dual low response to acetylsalicylic acid and clopidogrel is associated with myonecrosis and stent thrombosis after coronary stent implantation. Am Heart J 2010 May;159(5):891-898.e1.
2010-05 Halimeh S, Angelis G, Sander A, Edelbusch C, Rott H, Thedieck S, Mesters R, Schlegel N, Nowak-Göttl U. Multiplate whole blood impedance point of care aggregometry: preliminary reference values in healthy infants, children and adolescents. Klin Padiatr 2010 May;222(3):158-63.
2010-05 Hanke AA, Dellweg C, Kienbaum P, Weber CF, Görlinger K, Rahe-Meyer N. Effects of desmopressin on platelet function under conditions of hypothermia and acidosis: an in vitro study using multiple electrode aggregometry. Anaesthesia 2010 Jul;65(7):688-91. Epub 2010 May 11.
2010-05 Hanke AA, Roberg K, Monaca E, Sellmann T, Weber CF, Rahe-Meyer N, Görlinger K. Impact of platelet count on results obtained from multiple electrode platelet aggregometry (Multiplate). Eur J Med Res 2010 May 18;15(5):214-9.
2010-05 Morel-Kopp MC, Aboud M, Tan CW, Kulathilake C, Ward C. Whole blood impedance aggregometry detects heparin-induced thrombocytopenia antibodies. Thromb Res 2010 May;125(5):e234-9.
2010-05 Mortensen SB, Larsen SB, Grove EL, Kristensen SD, Hvas AM. Reduced platelet response to aspirin in patients with coronary artery disease and type 2 diabetes mellitus. Thromb Res 2010 Oct;126(4):e318-22. Epub 2010 May 7.
2010-05 Kalbantner K, Meyer-Lindenberg A, Mischke R. Platelet function in dogs with congenital portosystemic shunt. Vet J 2011 May;188(2):189-92. Epub 2010 May 23.
2010-05 Paniccia R, Antonucci E, Maggini N, Miranda M, Gori AM, Marcucci R, Giusti B, Balzi D, Prisco D, Abbate R. Comparison of methods for monitoring residual platelet reactivity after clopidogrel by point-of-care tests on whole blood in high-risk patients. Thromb Haemost 2010 Aug 2;104(2):287-92. Epub 2010 May 10.
2010-05 Penz SM, Bernlochner I, Tóth O, Lorenz R, Calatzis A, Siess W. Selective and rapid monitoring of dual platelet inhibition by aspirin and P2Y12 antagonists by using multiple electrode aggregometry. Thromb J 2010 May 13;8:9.
2010-05 Sibbing D, Gebhard D, Koch W, Braun S, Stegherr J, Morath T, Von Beckerath N, Mehilli J, Schömig A, Schuster T, Kastrati A. Isolated and interactive impact of common CYP2C19 genetic variants on the antiplatelet effect of chronic clopidogrel therapy. J Thromb Haemost 2010 Aug;8(8):1685-93. Epub 2010 May 21.
2010- 04 Behr T, Behr W & von Scheidt W. Monitoring of clopidogrel treatment by multiplate electrode platelet aggregometry. J Lab Med 34(2), 99 - 107.
2010-04 Skoric B, Milicic D, Lovric D, Gornik I, Skoric KN, Sertic J. Initial patency of the infarct-related artery in patients with acute ST elevation myocardial infarction is related to platelet response to aspirin. Int J Cardiol 2010 Apr 30;140(3):356-8. Epub 2008 Nov 30.
2010-04 Schober LJ, Khandoga AL, Penz SM, Siess W. The EP3-agonist sulprostone, but not prostaglandin E2 potentiates platelet aggregation in human blood. Thromb Haemost 2010 Jun;103(6):1268-9. Epub 2010 Apr 29.
2010-04 Mengistu AM, Mayer J, Boldt J, Röhm KD, Suttner SW. Usefulness of monitoring platelet function by multiple electrode aggregometry in primary coronary artery bypass surgery. J Cardiothorac Vasc Anesth 2011 Feb;25(1):42-7. Epub 2010 Apr 27.
2010-04 Melamed N, Yogev Y, Bouganim T, Altman E, Calatzis A, Glezerman M. The effect of menstrual cycle on platelet aggregation in reproductive-age women. Platelets 2010;21(5):343-7.
2010-03 Zürn CS, Geisler T, Gawaz M. ADP-receptor blockade: A case for personalised pharmacotherapy? Thromb Haemost 2010 Mar;103(3):496-506. Epub 2010 Jan 13.Review.
2010-03 Würtz M, Grove EL, Kristensen SD, Hvas AM. The antiplatelet effect of aspirin is reduced by proton pump inhibitors in patients with coronary artery disease. Heart 2010 Mar;96(5):368-71. Epub 2009 Nov 11.
2010-03 Weber CF, Dietrich W, Spannagl M, Hofstetter C, Jámbor C. A point-of-care assessment of the effects of desmopressin on impaired platelet function using multiple electrode whole-blood aggregometry in patients after cardiac surgery. Anesth Analg 2010 Mar 1;110(3):702-7.
2010-03 Reininger AJ, Bernlochner I, Penz SM, Ravanat C, Smethurst P, Farndale RW, Gachet C, Brandl R, Siess W. A 2-step mechanism of arterial thrombus formation induced by human atherosclerotic plaques. J Am Coll Cardiol 2010 Mar 16;55(11):1147-58.
2010-03 Kozek-Langenecker SA. Review Perioperative coagulation monitoring. Best Pract Res Clin Anaesthesiol 2010 Mar;24(1):27-40.
2010-03 Grove EL, Hvas AM, Johnsen HL, Hedegaard SS, Pedersen SB, Mortensen J, Kristensen SD. A comparison of platelet function tests and thromboxane metabolites to evaluate aspirin response in healthy individuals and patients with coronary artery disease. Thromb Haemost 2010 Jun;103(6):1245-53. Epub 2010 Mar 29.
2010-02 Siller-Matula JM, Christ G, Lang IM, Delle-Karth G, Huber K, Jilma B. Multiple electrode aggregometry predicts stent thrombosis better than the vasodilator-stimulated phosphoprotein phosphorylation assay. J Thromb Haemost 2010 Feb;8(2):351-9.
2010-02 Sibbing D, von Beckerath N, Morath T, Stegherr J, Mehilli J, Sarafoff N, Braun S, Schulz S, Schömig A, Kastrati A. Oral anticoagulation with coumarin derivatives and antiplatelet effects of clopidogrel. Eur Heart J 2010 May;31(10):1205-11. Epub 2010 Feb 16.
2010-02 Sibbing D, Stegherr J, Braun S, Mehilli J, Schulz S, Seyfarth M, Kastrati A, von Beckerath N, Schömig A. A double-blind, randomized study on prevention and existence of a rebound phenomenon of platelets after cessation of clopidogrel treatment. Am Coll Cardiol 2010 Feb 9;55(6):558-65.
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2010-02 Sibbing D, Schulz S, Braun S, Morath T, Stegherr J, Mehilli J, Schömig A, von Beckerath N, Kastrati A. Antiplatelet effects of clopidogrel and bleeding in patients undergoing coronary stent placement. J Thromb Haemost 2010 Feb;8(2):250-6.
2010-02 Sibbing D, Koch W, Gebhard D, Schuster T, Braun S, Stegherr J, Morath T, Schömig A, von Beckerath N, Kastrati A. Cytochrome 2C19*17 allelic variant, platelet aggregation, bleeding events, and stent thrombosis in clopidogrel-treated patients with coronary stent placement. Circulation 2010 Feb 2;121(4):512-8.
2010-02 Scharbert G, Kalb ML, Essmeister R, Kozek-Langenecker SA. Mild and moderate hypothermia increases platelet aggregation induced by various agonists: a whole blood in vitro study. Platelets 2010 Feb;21(1):44-8.
2010-02 Demler C, Bühler B, Menin L, Stöcklin R, Wilmer M, Ernst B, Perchuc AM. Platelet-active substances in the venom of Bothrops moojeni snake-a novel evaluation method using whole blood aggregometry. Platelets. 2010 Feb;21(1):20-8.
2010-02 Solomon C, Hartmann J, Osthaus A, Schöchl H, Raymondos K, Koppert W, Rahe-Meyer N. Platelet concentrates transfusion in cardiac surgery in relation to preoperative point-of-care assessment of platelet adhesion and aggregation. Platelets 2010;21(3):221-8.
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2010-01 Rahe-Meyer, N.; Solomon, C.; Tokuno, M.-L.; Winterhalter, M.; Shrestha, M.; Hahn, A. & Tanaka, K. (2010), Comparative assessment of coagulation changes induced by two different types of heart-lung machine., Artif Organs 34(1), 3--12.
2009-12 Mueller T, Dieplinger B, Poelz W, Haltmayer M. Utility of the PFA-100 instrument and the novel multiplate analyzer for the assessment of aspirin and clopidogrel effects on platelet function in patients with cardiovascular disease. Clin Appl Thromb Hemost 2009 Dec;15(6):652-9.
2009-12 Boldt J, Mengistu A. Balanced hydroxyethylstarch preparations: are they all the same? In-vitro thrombelastometry and whole blood aggregometry. Eur J Anaesthesiol 2009 Dec;26(12):1020-5.
2009-12 Boldt J; Mengistu A. A New Plasma-Adapted Hydroxyethyl Starch Preparation: In Vitro Coagulation Studies. J Cardiothorac Vasc Anesth 2010 Jun;24(3):394-8. Epub 2009 Dec 11.
2009-12 Baumgarten A, Wilhelmi M, Kalbantner K, Ganter M, Mischke R. Measurement of platelet aggregation in ovine blood using a new impedance aggregometer. Vet Clin Pathol 2010 Jun;39(2):149-56. Epub 2009 Dec 8.
2009-12 Bäck J, Lang MH, Elgue G, Kalbitz M, Sanchez J, Ekdahl KN, Nilsson B. Distinctive regulation of contact activation by antithrombin and C1-inhibitor on activated platelets and material surfaces. Biomaterials 2009 Dec;30(34):6573-80.
2009-11 Truss NJ, Armstrong PC, Liverani E, Vojnovic I, Warner TD. Heparin but not citrate anticoagulation of blood preserves platelet function for prolonged periods. J Thromb Haemost 2009 Nov;7(11):1897-905.
2009-11 Schuhmann CG, Sohn HY, Nagel J, Spannagl M, Klauss V, Krötz F. Clinical management of clopidogrel inefficiency by point of care platelet function testing and individual adjustment of anti-platelet therapy-initial experiences. Platelets 2009 Nov;20(7):498-504.
2009-11 Elalamy I, Galea V, Hatmi M, Gerotziafas GT. Heparin-induced multiple electrode aggregometry: a potential tool for improvement of heparin-induced thrombocytopenia diagnosis. J Thromb Haemost 2009 Nov;7(11):1932-4.
2009-11 Braun S, von Beckerath N, Ellert J, Kastrati A, Schömig A, Vogt W, Sibbing D. Assessment of platelet function in whole blood by multiple electrode aggregometry: transport of samples using a pneumatic tube system. Am J Clin Pathol. 2009 Nov;132(5):802-3; author reply 803-4.
2009-11 Bolliger D, Seeberger MD, Tanaka KA, Dell-Kuster S, Gregor M, Zenklusen U, Grapow M, Tsakiris DA, Filipovic M. Pre-analytical effects of pneumatic tube transport on impedance platelet aggregometry. Platelets 2009 Nov;20(7):458-65.
2009-10 Kalbantner K, Baumgarten A, Mischke R. Measurement of platelet function in dogs using a novel impedance aggregometer. Vet J 2010 Aug;185(2):144-51. Epub 2009 Oct 29.
2009-09 Pedersen SB, Grove EL, Nielsen HL, Mortensen J, Kristensen SD, Hvas AM. Evaluation of aspirin response by Multiplate whole blood aggregometry and light transmission aggregometry. Platelets 2009 Sep;20(6):415-20.
2009-09 De Luca G, Santagostino M, Secco GG, Cassetti E, Giuliani L, Franchi E, Coppo L, Iorio S, Venegoni L, Rondano E, Dell'Era G, Rizzo C, Pergolini P, Monaco F, Bellomo G, Marino P. Mean platelet volume and the extent of coronary artery disease: results from a large prospective study. Atherosclerosis 2009 Sep;206(1):292-7.
2009-08 Siller-Matula JM, Gouya G, Wolzt M, Jilma B. Cross validation of the Multiple Electrode Aggregometry. A prospective trial in healthy volunteers. Thromb Haemost 2009 Aug;102(2):397-403.
2009-08 Milicic D, Skoric B, Lovric D. Drug-specific thienopyridine resistance in patient with recurrent coronary stent thrombosis. J Invasive Cardiol. 2009 Aug;21(8):E157-60.
2009-08 Awidi A, Maqablah A, Dweik M, Bsoul N, Abu-Khader A. Comparison of platelet aggregation using light transmission and multiple electrode aggregometry in Glanzmann thrombasthenia. Platelets 2009 Aug;20(5):297-301.
2009-07 Jámbor C, Weber CF, Gerhardt K, Dietrich W, Spannagl M, Heindl B, Zwissler B. Whole blood multiple electrode aggregometry is a reliable point-of-care test of aspirin-induced platelet dysfunction. Anesth Analg 2009 Jul;109(1):25-31.
2009-06 Velik-Salchner C, Maier S, Innerhofer P, Kolbitsch C, Streif W, Mittermayr M, Praxmarer M, Fries D. An assessment of cardiopulmonary bypass-induced changes in platelet function using whole blood and classical light transmission aggregometry: the results of a pilot study. Anesth Analg 2009 Jun;108(6):1747-54.
2009-06 Paniccia R, Antonucci E, Maggini N, Romano E, Gori AM, Marcucci R, Prisco D, Abbate R. Assessment of platelet function on whole blood by multiple electrode aggregometry in high-risk patients with coronary artery disease receiving antiplatelet therapy. Am J Clin Pathol 2009 Jun;131(6):834-42.
2009-06 Gawaz M, Geisler T. Coronary artery disease: Platelet activity: an obstacle for successful PCI. Nat Rev Cardiol 2009 Jun;6(6):391-2.
2009-05 Zavodnik IB, Lapshina E, Sudnikovich E, Boncler M, Luzak B, Rózalski M, Helińska M, Watała C. Structure, stability, and antiplatelet activity of O-acyl derivatives of salicylic acid and lipophilic esters of acetylsalicylate. Pharmacol Rep. 2009 May-Jun;61(3):476-89.
2009-04 Sibbing D, Morath T, Stegherr J, Braun S, Vogt W, Hadamitzky M, Schömig A, Kastrati A, von Beckerath N. Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel. Thromb Haemost 2009 Apr;101(4):714-9.
2009-04 Siller-Matula JM, Haberl K, Prillinger K, Panzer S, Lang I, Jilma B. The effect of antiplatelet drugs clopidogrel and aspirin is less immediately after stent implantation. Thromb Res 2009 Apr;123(6):874-80.
2009-04 Jilma-Stohlawetz P, Eichelberger B, Horvath M, Jilma B, Panzer S. In vitro platelet function of platelet concentrates prepared using three different apheresis devices determined by impedance and optical aggregometry. Transfusion 2009 Aug;49(8):1564-8.
2009-04 Can MM, Tanboğa IH, Türkyilmaz E, Karabay CY, Akgun T, Koca F, Tokgoz HC, Keles N, Ozkan A, Bezgin T, Ozveren O, Sonmez K, Sağlam M, Ozdemir N, Kaymaz C. The risk of false results in the assessment of platelet function in the absence of antiplatelet medication: comparison of the PFA-100, multiplate electrical impedance aggregometry and verify now assays. Thromb Res 2010 Apr;125(4):e132-7.
2009-03 Sibbing D, Braun S, Morath T, Mehilli J, Vogt W, Schömig A, Kastrati A, von Beckerath N. Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis., J Am Coll Cardiol 2009 Mar 10;53(10):849-56.
2009-03 Scharbert G, Auer A, Kozek-Langenecker S. Evaluation of the Platelet Mapping Assay on rotational thromboelastometry ROTEM. Platelets 2009 Mar;20(2):125-30.
2009-02 Rahe-Meyer N, Winterhalter M, Boden A, Froemke C, Piepenbrock S, Calatzis A, Solomon C. Platelet concentrates transfusion in cardiac surgery and platelet function assessment by multiple electrode aggregometry. Acta Anaesthesiol Scand 2009 Feb;53(2):168-75.
2009-02 Kalb ML, Potura L, Scharbert G, Kozek-Langenecker SA. The effect of ex vivo anticoagulants on whole blood platelet aggregation. Platelets 2009 Feb;20(1):7-11.
2009-02 Gremmel T, Steiner S, Seidinger D, Koppensteiner R, Panzer S, Kopp CW. Comparison of methods to evaluate clopidogrel-mediated platelet inhibition after percutaneous intervention with stent implantation. Thromb Haemost 2009 Feb;101(2):333-9.
2009-02 Boldt J, Suttner S, Brosch C, Lehmann A, Mengistu A. Influence on coagulation of a potato-derived hydroxethylstarch (HES 130/0.42) and a maize-derived hydroxethylstarch (HES 130/0.4) in patients undergoing cardiac surgery. Br J Anaesth. 2009 Feb;102(2):191-7. Epub 2008 Dec 10.
2009-01 Steinlechner B, Dworschak M, Birkenberg B, Duris M, Zeidler P, Fischer H, Milosevic L, Wieselthaler G, Wolner E, Quehenberger P, Jilma B. Platelet dysfunction in outpatients with left ventricular assist devices. Ann Thorac Surg. 2009 Jan;87(1):131-7.
2009-01 Siller-Matula JM, Spiel AO, Lang IM, Kreiner G, Christ G, Jilma B. Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel. Am Heart J. 2009 Jan;157(1):148.e1-5. Epub 2008 Nov 6.
2009-01 Jámbor C, Weber CF, Lau A, Spannagl M, Zwissler B. Multiple electrode aggregometry for ex-vivo detection of the anti-platelet effect of non-opioid analgesic drugs. Thromb Haemost. 2009 Jan;101(1):207-9.
2008-12 Velik-Salchner C, Maier S, Innerhofer P, Streif W, Klingler A, Kolbitsch C, Fries D. Point-of-care whole blood impedance aggregometry versus classical light transmission aggregometry for detecting aspirin and clopidogrel: the results of a pilot study. Anesth Analg. 2008 Dec;107(6):1798-806.
2008-12 Rahe-Meyer N, Winterhalter M, Hartmann J, Pattison A, Hecker H, Calatzis A, Solomon C. An evaluation of cyclooxygenase-1 inhibition before coronary artery surgery: aggregometry versus patient self-reporting. Anesth Analg. 2008 Dec;107(6):1791-7.
2008-11 Siller-Matula JM, Lang I, Christ G, Jilma B. Calcium-channel blockers reduce the antiplatelet effect of clopidogrel. J Am Coll Cardiol. 2008 Nov 4;52(19):1557-63.
2008-11 Ibrahim K, Hass N, Kolschmann S, Strasser RH, Braun-Dullaeus RC. Reversible clopidogrel resistance due to right ventricular myocardial infarction: risk factor of recurrent stent thrombosis? Clin Res Cardiol. 2008 Nov;97(11):797-800. Epub 2008 Jul 28.
2008-10 Breugelmans J, Vertessen F, Mertens G, Gadisseur A, Van der Planken M. Multiplate whole blood impedance aggregometry: a recent experience. Thromb Haemost. 2008 Oct;100(4):725 6.
2008-08 Mengistu AM, Röhm KD, Boldt J, Mayer J, Suttner SW, Piper SN. The influence of aprotinin and tranexamic acid on platelet function and postoperative blood loss in cardiac surgery. Anesth Analg. 2008 Aug;107(2):391-7.
2008-06 Sibbing D, Busch G, Braun S, Jawansky S, Schömig A, Kastrati A, Ott I, von Beckerath N. Impact of bivalirudin or unfractionated heparin on platelet aggregation in patients pretreated with 600 mg clopidogrel undergoing elective percutaneous coronary intervention. Eur Heart J. 2008 Jun;29(12):1504-9. Epub 2008 May 7.
2008-06 Johnson A, Dovlatova N, Heptinstall S. Multiple electrode aggregometry and P2Y(12) antagonists. Thromb Haemost. 2008 Jun;99(6):1127-9.
2008-06 Görlinger K, Jambor C, Dirkmann D, Dusse F, Hanke A, Adamzik M, Hartmann M, Philipp S, Weber AA, Rahe-Meyer N. Platelet function analysis with point-of-care methods. Herz. 33(4): 297--305.
2008-06 Koziński M, Bielis L, Wiśniewska-Szmyt J, Sukiennik A, Grabczewska Z, Swiatkiewicz I, Ziołkowski M, Rość D, Kubica J. Increased morning ADP-dependent platelet aggregation persists despite dual antiplatelet therapy in patients with first ST-segment elevation myocardial infarction: Preliminary report. Cardiol J. 2008;15(6):530-6.
2008-05 Dobaczewski M, Golański J, Kowalski T, Nocuń M, Rózalski M, Kostka B, Ulicna O, Mussur M, Markuszewski L, Watała C. Can we use adenosine diphosphate (ADP) to study "aspirin resistance"? The Janus faces of ADP-triggered platelet aggregation. Pharmacol Rep. 2008 May-Jun;60(3):361-8.
2008-04 Seibel K, Berdat P, Boillat C, Wagner B, Zachariou Z, Kessler U. Hemostasis management in pediatric mechanical circulatory support. Ann Thorac Surg. 2008 Apr;85(4):1453-6.
2008-04 Müller-Schunk S, Linn J, Peters N, Spannagl M, Deisenberg M, Brückmann H, Mayer TE. Monitoring of clopidogrel-related platelet inhibition: correlation of nonresponse with clinical outcome in supra-aortic stenting. AJNR Am J Neuroradiol. 2008 Apr;29(4):786-91. Epub 2008 Jan 25.
2008-04 Kirkeby A, Torup L, Bochsen L, Kjalke M, Abel K, Theilgaard-Monch K, Johansson PI, Bjørn SE, Gerwien J, Leist M. High-dose erythropoietin alters platelet reactivity and bleeding time in rodents in contrast to the neuroprotective variant carbamyl-erythropoietin (CEPO). Thromb Haemost. 2008 Apr;99(4):720-8.
2008-04 Haas T, Fries D, Holz C, Innerhofer P, Streif W, Klingler A, Hanke A, Velik-Salchner C. Less impairment of hemostasis and reduced blood loss in pigs after resuscitation from hemorrhagic shock using the small-volume concept with hypertonic saline/hydroxyethyl starch as compared to administration of 4% gelatine or 6% hydroxyethyl starch solution. Anesth Analg. 2008 Apr;106(4):1078-86, table of contents.
2008-02 Mengistu AM, Wolf MW, Boldt J, Röhm KD, Lang J, Piper SN. Evaluation of a new platelet function analyzer in cardiac surgery: a comparison of modified thromboelastography and whole-blood aggregometry. J Cardiothorac Vasc Anesth. 2008 Feb;22(1):40-6. Epub 2007 May 23.
2008-01 Sibbing D, Braun S, Jawansky S, Vogt W, Mehilli J, Schömig A, Kastrati A, von Beckerath N. Assessment of ADP-induced platelet aggregation with light transmission aggregometry and multiple electrode platelet aggregometry before and after clopidogrel treatment. Thromb Haemost. 2008 Jan;99(1):121-6.
2007-12 Grumann T, Diehl P, Bode C, Moser M. [Is stent thrombosis the new Achilles heel of interventional cardiology? State of the Art clinical trials, causes and approaches for prevention]. Hamostaseologie. 2007 Dec;27(5):344-50. German.
2007-11 Scharbert G, Kalb ML, Duris M, Marschalek C, Kozek-Langenecker SA. Garlic at dietary doses does not impair platelet function. Anesth Analg. 2007 Nov;105(5):1214-8, table of contents.
2007-11 Görlinger K, Jambor C, Hanke A A, Dirkmann D, Adamzik M, Hartmann M, Rahe-Meyer N. Perioperative coagulation management and control of platelet transfusion by point-of-care platelet function analysis. Transfus Med and Hemother. 2007; 34, 396-411.
2007-10 Hellstern P, Stürzebecher U, Wuchold B, Haubelt H, Seyfert UT, Bauer M, Vogt A, Stürzebecher J. Preservation of in vitro function of platelets stored in the presence of a synthetic dual inhibitor of factor Xa and thrombin. J Thromb Haemost. 2007 Oct;5(10):2119-26. Epub 2007 Jul 31.
2007-08 von Pape KW, Dzijan-Horn M, Bohner J, Spannagl M, Weisser H, Calatzis A. [Control of aspirin effect in chronic cardiovascular patients using two whole blood platelet function assays. PFA-100 and Multiplate]. Hamostaseologie. 2007 Aug;27(3):155-60; quiz 161-2. German.
2007-07 Bergmann L, Kienbaum P, Görlinger K, Peters J. Uneventful removal of an epidural catheter guided by impedance aggregometry in a patient with recent coronary stenting and treated with clopidogrel and acetylsalicylic acid. Reg Anesth Pain Med. 2007 Jul-Aug;32(4):354-7.
2007-05 Seyfert UT, Haubelt H, Vogt A, Hellstern P. Variables influencing Multiplate(TM) whole blood impedance platelet aggregometry and turbidimetric platelet aggregation in healthy individuals. Platelets. 2007 May;18(3):199-206.
2007-05 Mueller T, Dieplinger B, Poelz W, Calatzis A, Haltmayer M. Utility of whole blood impedance aggregometry for the assessment of clopidogrel action using the novel Multiplate analyzer--comparison with two flow cytometric methods. Thromb Res. 2007;121(2):249-58. Epub 2007 May 7.
2007-03 Penz SM, Reininger AJ, Toth O, Deckmyn H, Brandl R, Siess W. Glycoprotein Ibalpha inhibition and ADP receptor antagonists, but not aspirin, reduce platelet thrombus formation in flowing blood exposed to atherosclerotic plaques. Thromb Haemost. 2007 Mar;97(3):435-43.
2007-02 Boldt J, Wolf M, Mengistu A. A new plasma-adapted hydroxyethylstarch preparation: in vitro coagulation studies using thrombelastography and whole blood aggregometry. Anesth Analg. 2007 Feb;104(2):425-30.
2006-12 Tóth O, Calatzis A, Penz S, Losonczy H, Siess W. Multiple electrode aggregometry: a new device to measure platelet aggregation in whole blood. Thromb Haemost. 2006 Dec;96(6):781-8.
2006-04 Scharbert G, Kalb M, Marschalek C, Kozek-Langenecker SA. The effects of test temperature and storage temperature on platelet aggregation: a whole blood in vitro study. Anesth Analg. 2006 Apr;102(4):1280-4.
Further Information
Quotations
"Platelet hyperreactivity in MEA might be a better risk predictor for
stent thrombosis than the assessment of the specific clopidogrel effect with the VASP
assay."
Jolanta M. Siller-Matula MD et al, Department of Clinical Pharmacology, Medical University of Vienna, Austria
"On-site testing of clopidogrel-related platelet inhibition by impedance aggregometry in neurointerventional radiology is feasible. … Near-patient testing of platelet inhibition before neurointerventional stent placement seems reasonable to adjust the antiplatelet protocol individually if required and has the potential to reduce the thromboembolic complications in interventional neuroradiology.“
Müller-Schunk S, Linn J, Peters N, Spannagl M, Deisenberg M, Brückmann H, Mayer TE. Monitoring of clopidogrel-related platelet inhibition: correlation of nonresponse with clinical outcome in supra-aortic stenting. AJNR Am J Neuroradiol. 2008 Apr;29(4):786-91.
“The Multiplate Analyzer ASPItest is highly sensitive towards aspirin, easy to handle, non-expensive and the tests are reproducible.“
Steinlechner B. et al, Division of Cardiothoracic and Vascular Anesthesia, University Hospital Vienna, Vienna, Austria: Anesthesiology 2007; 107: A1724
".. the Multiplate has a number of user-friendly characteristics: it is semi-automated, needs no preparation of platelet-rich plasma and performs a dual measurement as internal control. In addition, it is also patient-friendly since only 1.2 ml of whole blood is required for the analysis of four agonists.. A good sensitivity for the detection of low aspirin and clopidogrel responders was observed.." Multiplate whole blood impedance aggregometry: A recent experience.
Jaimie Breugelmans, Francine Vertessen, Gerhard Mertens, Alain Gadisseur, Marc Van der Planken. Thrombosis and Haemostasis 2008 100 4: 725-726.
“Patients requiring postoperative blood transfusion showed lower preoperative ADP-mediated aggregometry compared with nontransfused patients…“
Mengistu AM, Wolf MW, Boldt J, Röhm KD, Lang J, Piper SN. Evaluation of a new platelet function analyzer in cardiac surgery: a comparison of modified thromboelastography and whole-blood aggregometry. J Cardiothorac Vasc Anesth. 2008 Feb;22(1):40-6.
“MEA is capable of detecting the effect of clopidogrel treatment and the results of MEA, prior to, and after clopidogrel treatment, correlate well with LTA. No centrifugation steps are needed for MEA and assessment of platelet aggregation can be done in approximately 10 min.“
Sibbing D, Braun S, Jawansky S, Vogt W, Mehilli J, Schömig A, Kastrati A, von Beckerath N. Division of Cardiology, German Heart Center in Munich, Munich, Germany; Eur Heart J. 2008 Jun; 29(12):1504-9
“Multiplate uses anticoagulated whole blood for analysis. Whole blood is the physiological environment where platelet function takes place in vivo, and the use of whole blood for in vitro testing eliminates the need for time-consuming centrifugation steps required for Born aggregation measurements.“
Görlinger K., Jambor C., Hanke A.A., Dirkmann D., Adamzik M., Hartmann M., Rahe-Meyer N., Perioperative Coagulation Management and Control of Platelet Transfusion by Point-of-Care Platelet Function Analysis; Transfus Med Hemother 2007;34:396–411
“Since hirudin and other direct acting thrombin inhibitors do not reduce the concentration of divalent cations in plasma, these can be considered to provide a more physiological environment than the use of sodium citrate.“
Andrew Johnson, Natalia Dovlatova, Stan Heptinstall. Cardiovascular Medicine, University of Nottingham, Nottingham, UK. Multiple electrode aggregometry and P2Y12 antagonists. Thromb Haemost. 2008 Jun;99(6):1127-9
“Low response to aspirin is associated with an increase of PCI-related myocardial infarction and combined low response to aspirin and clopidogrel increase the risk for 6-month major adverse cardiac events.”
P. Eshtehardi, S. Windecker, O.M. Hess, S. Cook, M. Billinger, M. Togni, R. Vogel, C. Seiler, B. Meier, P. Wenaweser. Department of Cardiology, Swiss Cardiovascular Center Bern, University Hospital, Bern, Switzerland; European Heart Journal 2008 29 (Abstract Supplement), 832.
“In conclusion, MEA is a fast, convenient platelet-function testing method which enables to measure aggregation in whole diluted blood, with very convergent results to those obtained by single platelet counting.“
Tóth O., Calatzis A., Penz S., Losonczy H, Siess W. Institute for Prevention of Cardiovascular Diseases, University of Munich, Munich, Germany. Thromb Haemost. 2006 Dec;96(6):781-8
Further Information