Platelet inhibition - certified
Aspirin®, clopidogrel, prasugrel, IIbIIIa antagonists: Clinically predictive assessment of adequate patient response:
Adequate platelet inhibition is of pivotal importance for the clinical management of patients at high risk for arterial thrombosis, e.g. after stent placement or in acute coronary syndrome (ACS).
Clopidogrel or aspirin® ”resistance” (reduced effect of the prescribed drug in the patient) is associated with a significantly increased risk of arterial thromboembolism.
Multiplate® is highly sensitive for the detection of Aspirin®, clopidogrel, prasugrel, IIbIIIa receptor antagonists and other platelet inhibitors. The largest study to date evaluating the clinical impact of clopidogrel resistance (Sibbing D et al. J Am Coll Cardiol 2009; 53(10):849-56) has shown that patients, stratified as inadequate responders according to Multiplate® analysis exhibited a 9.4 fold increased risk of early stent thrombosis. Another study from the university of Vienna (Siller-Matula JM et al. J Thromb Haemost. 2010 Feb;8(2):351-9) has confirmed the excellent predictivity of Multiplate analysis in this application. The predictivity of Multiplate® analysis has also been demonstrated in neuroradiology (Mueller-Schunk S et al. Am J Neuroradiol. 2008 Apr;29(4):786-91).
Platelet function - certified
Sensitive and clinically predictive assessment of perioperative platelet function:
Platelet dysfunction can cause hemorrhagic complications during invasive procedures.
Multiplate® enables the rapid verification or exclusion of drug induced or disease related platelet disorders. The clinical predictivity of the perioperative use of Multiplate® has been validated in several clinical studies (Rahe-Meyer N et al. Acta Anaesthesiol Scand. 2009 Feb;53(2):168-75. Rahe-Meyer N et al. Anesth Analg. 2008 Dec;107(6):1791-7. Mengistu AM et al. J Cardiothorac Vasc Anesth. 2008 Feb;22(1):40-6).
Screening for platelet defects:
Platelet defects like Glanzmann´s thrombasthenia or the Bernard-Soulier syndrome can be detected directly in whole blood (Awidi A et al. Platelets. 2009 Aug;20(5):297-301).
Functional detection of heparin induced thrombocytopenia (HIT):
Recent reports from the Tenon Hospital in Paris (Elalamy I et al; J Thromb Haemost. 2009 Nov;7(11):1932-4) and the university of Sydney (Morel-Kopp MC at al, Thromb Res. 2010 May;125(5):e234-9) show that Multiplate can be used for functional detection of HIT. Advantages include a small sample volume of donor blood, simple and rapid procedure as well as a high sensitivity for HIT antibodies with platelet-activating properties.
Experimental models and animal models:
Multiplate® is used by many academic pharmacological departments and drug companies for the experimental assessment of platelet function in general and platelet function inhibitors in particular. Blood of mice, rats, dogs and other animal species can be analyzed. Only 0.3 ml blood is necessary per test. For research use a special test cell with a reduced sample volume of 175 µl is available.
Multiplate® - the new standard for platelet diagnostics.