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Multiplate® tests:

Using the different test procedures available for the Multiplate® comprehensive information on platelet function and antiplatelet therapy can be obtained.

  • ASPItest: Activation by arachidonic acid, the substrate of the cyclooxygenase (COX). COX forms Thromboxane A2 (TXA2) which is a potent platelet agonist.

  • COLtest: Collagen activates the collagen receptor, which leads to a release of endogenous arachidonic acid, which is converted to TXA2 and activates the platelet.

  • TRAPtest: TRAP-6 stimulates the thrombin receptor on the platelet surface. Thrombin is a very potent platelet activator. Its action is not blocked by Aspirin® or clopidogrel. TRAPtest allows to detect GpIIb/IIIa antagonists also in samples treated by Aspirin® or clopidogrel.

  • ADPtest: ADP stimulates platelet activation by the ADP receptors. The most important ADP receptor (P2Y12) is blocked by clopidogrel, prasugrel and ticlopidine.

  • ADPtest HS: The addition of the endogenous inhibitor PGE1 makes ADPtest HS more sensitive towards the effects of clopidogrel and related drugs compared to ADPtest.

The following terms are registered trademarks: Aspirin® (Bayer AG, Leverkusen), Cangrelor® (The Medicines Company, Parsipanny, USA), Reopro® (Eli Lilly and Company, Indianapolis, USA), Aggrastat® (MSD, Haar), Integrilin® (GlaxoSmithKline, Munich).

 
Multiplate System